The first three spots in the Champions Cup quarterfinals will start to be decided beginning on Tuesday | OneFootball

MIAMI — The 2025 Concacaf Champions Cup continues on Tuesday with three second leg matches in the Round of 16.

Columbus Crew will seek a comeback on its home turf, looking to overturn a 3-nil deficit to fellow MLS club LAFC. Cruz Azul and Seattle Sounders FC have everything to play for after a scoreless first leg. Tigres UANL and FC Cincinnati will meet in the night's last match, looking to resolve a 1-1 draw in the opening encounter.

The winners on aggregate will advance to the quarterfinals. Away goals serve as the primary tiebreaker. If necessary, extra time and a penalty shootout will decide a winner.

Columbus Crew vs. LAFC

The Columbus Crew hosts Los Angeles FC at Lower.com Field in Columbus, Ohio, USA. LAFC won the first leg 3-nil and will look to see out its lead into a spot in the quarterfinals.

The reigning Leagues Cup winners and 2024 Concacaf Champions Cup runners-up face an uphill battle, needing at least three goals to tie on aggregate and avoid giving up away goals. The Crew will look to Diego Rossi and Jacen Russell-Rowe, among others, to spark its offense.

LAFC is led offensively by Denis Bouanga, who scored twice in the opening match, and defensively by goalkeeper Hugo Lloris, who collected his second clean sheet. In the first leg, 21-year-old Nathan Ordaz made history by becoming the youngest U.S.-born player to score in the Champions Cup for the club.

No MLS club has ever overturned a 3-0 first leg away defeat in tournament history,

The winner of this series will play Inter Miami CF or Cavalier FC in the quarterfinals.

Cruz Azul vs. Seattle Sounders

Cruz Azul hosts Seattle Sounders FC at Estadio Olímpico Universitario in Mexico City, Mexico.

After a scoreless draw in the first leg in Seattle, Cruz Azul returns home with hopes of punching their ticket to the next round. La Máquina has advanced in all three two-leg series versus MLS opposition in the modern era of the competition. Ángel Sepúlveda, tied for the tournament lead with three goals, missed the first leg but can be a massive factor in Mexico City.

Seattle Sounders FC features a potent and experienced attack with U.S. national team forwards Jordan Morris, Paul Arriola, and Jesus Ferreira. The U.S. club will seek to be the first to score against Cruz Azul in the 2025 edition.

The winner will play either CD Guadalajara or Club América in the quarterfinals.

Tigres UANL vs. FC Cincinnati

Tigres UANL hosts FC Cincinnati at Estadio Universitario in San Nicolás de los Garza, Nuevo León, México.

The sides drew 1-1 in the first leg in Cincinnati last Tuesday. Nicolás Ibáñez scored the lone goal for the Mexican side, who were backed with five saves by Nahuel Guzmán in an excellent performance.

Pavel Bucha found the back of the net for the U.S. side, co-leading the Golden Boot race with three goals. Newcomer Kévin Denkey has also played an integral role, providing the assist in the first leg and two goals in the campaign.

Since the start of the modern era in 2008, Tigres has avoided defeat in 20 of its 22 matches against MLS teams in the Champions Cup. The Liga MX club has been unbeaten in its last six home matches against MLS opposition, eliminated in the 2024 quarterfinals by Columbus Crew on penalties.

The winner of this series will advance to play either LA Galaxy or CS Herediano.