Manchester United vs Lyon - Preview, prediction, team news and lineups | OneFootball

Manchester United have won both previous home games against Olympique Lyonnais, although les Gones have won four of six visits to England since the most-recent of those.

Manchester United vs Olympique Lyonnais Preview

After a thoroughly entertaining first leg in France, it is all to play for at Old Trafford. A week ago, it was Lyon who struck first; Thiago Almada's free-kick bounced beyond André Onana, only for Leny Yoro to equalise with a header right on the cusp of half time. Then, with just two minutes to play, Joshua Zirkzee had seemingly won it for Man United, only for another Onana error to present Rayan Cherki with a 95th minute equaliser, sparking wild celebrations. Thus, 2-2 it finished in Décines-Charpieu, but there must be a winner by the end of the night this time.

For Manchester United, they remain unbeaten in this season's Europa League, winning six of 11 fixtures so far. However, to salvage this campaign, Rúben Amorim's team simply must go all the way and capture the trophy in Bilbao next month. That's because the Red Devils languish down in 14th in the league, and Sunday's 4-1 hammering at Newcastle means they are now guaranteed to end this Premier League season with their lowest-ever points tally in the competition. All of Man United's eggs are firmly in the Europa League basket, hence why defeat here would be catastrophic.

As for Olympique Lyonnais, they're aiming to reach only the club's fifth major European semi-final, having never previously featured in the final of any UEFA competition. Les Gones have lost only once in the Europa League so far, smashing Steaua București 7-1 in the round of 16, but will require an historic victory here to reach the semis. Paulo Fonseca's side are in good form in Ligue 1, winning seven of their last nine, most-recently defeating Auxerre 3-1 at the weekend. This saw Lyon move up to fourth, thereby occupying the last Champions League place, ahead of Sunday's huge Derby Rhône-Alpes against second-bottom Saint-Étienne. Before then, can Les Gones add to Man United's misery and silence Old Trafford? Athletic Club or Rangers await the winners in the semi-finals.

Manchester United vs Olympique Lyonnais Head-to-Head Record

Manchester United Team News

Lisandro Martínez, Matthijs de Ligt Jonny Evans, Toby Collyer and now Joshua Zirkzee are sidelined, limiting Rúben Amorim's options. The biggest talking point surrounds his goalkeeper. André Onana did not travel to Newcastle this weekend following a string of errors, but deputy Altay Bayındır didn't exactly cover himself in glory on Tyneside either, so who will be donning the gloves?

Patrick Dorgu, Harry Maguire, Casemiro and Rasmus Højlund could return, having been rested on Sunday. Meantime, Luke Shaw came off the bench against Newcastle, his first appearance since 1 December, while Kobbie Mainoo has been introduced as a substitute during the last two matches, potentially building up his fitness with a start here in mind.

Manchester United predicted lineup vs Olympique Lyonnais: (3-4-3): Onana; Yoro, Maguire, Mazraoui; Dalot, Ugarte, Mainoo, Dorgu; Garnacho, Fernandes, Højlund.

Manchester United Player to Watch vs Olympique Lyonnais

Bruno Fernandes continues to be Man United's talisman, scoring 16 times this season, including a hat-trick against Real Sociedad in the previous round, so can he fire them into the semis?

Olympique Lyonnais Team News

Manager Paulo Fonseca continues to serve a seven-month touchline ban in Ligue 1, but he is allowed to patrol his technical error in this competition. He could name an unchanged lineup from the first leg, featuring Georges Mikautadze leading the attack, chosen over captain Alexandre Lacazette.

Compared to the weekend win, this would see Ainsley Maitland-Niles return at right-back, while Paul Akouokou and Jordan Veretout will be hoping to get the nod over former Man United man Nemanja Matić at the base of midfield. Wingers Malick Fofana and Ernest Nuamah are sidelined long-term.

Olympique Lyonnais predicted lineup vs Manchester United: (4-2-3-1): Perri; Maitland-Niles, Mata, Niakhaté, Tagliafico; Akouokou, Veretout, Cherki, Tolisso, Almada; Mikautadze,

Olympique Lyonnais Player to Watch vs Manchester United

Georges Mikautadze's goal at Stade Abbé-Deschamps on Sunday took his tally to 15 for the season, four of which have come in the Europa League, so will he be Lyon's hero in Manchester?

Manchester United vs Olympique Lyonnais Prediction

We are backing Lyon to progress to the semi-finals, simply due to how rotten Man United have been all season, and we think their luck will run out: Manchester United 1-2 Olympique Lyonnais.

How to watch Manchester United vs Olympique Lyonnais Europa League game on TV channel?

How to watch Manchester United vs Olympique Lyonnais Europa League game on live streaming?

What is the date and kick-off time for Manchester United vs Olympique Lyonnais in the Europa League?

Manchester United vs Olympique Lyonnais in the Europa League takes place on Thursday 17 April 2025, with kick off at 20:00 (BST), 15:00 (EDT) & 12:00 (PDT).